Dsg2 gene and cancer

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August undefined, 2024

WebTissue proteome. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC . DSG2. WebDSC2 promoter methylation is associated with Breast Cancer. Homozygous founder mutation in DSC2 gene identified among Italian arrhythmogenic cardiomyopathy …

TROP2 Down-regulated DSG2 to Promote Gastric Cancer Cell

WebSep 16, 2016 · This study determined Dsg2 expression in non-small cell lung cancer (NSCLC) tissue specimens for association with clinicopathological and survival data and then assessed the effect of Dsg2 knockdown on regulation of NSCLC cell malignant behaviors in vitro and in nude mouse xenografts. WebClinVar archives and aggregates information about relationships among variation and human health. bofrost personalabteilung

A Five-Genes-Based Prognostic Signature for Cervical Cancer

WebThe gene view histogram is a graphical view of mutations across DSG2. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. Web872 Asian Pacific Journal of Cancer Prevention, Vol 15, 2014 proportion of positive cells in high-risk SCC than in low-risk SCC (Kurzen et al., 2003; Brennan et al., 2009); while in diffuse-type gastric carcinoma, decreased expression of DSG2 is associated with loss of tumor differentiation and poor prognosis (Yashiro et al., 2006). Recently, we WebSep 4, 2014 · Consistent with these findings, analyses of human colon cancers demonstrated increased Dsg2 protein expression. Taken together, these data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR signaling. … bofrost passwort

Function and cancer genomics of FAT family genes (review)

DSG2 desmoglein 2 [Homo sapiens (human)] - Gene - NCBI

WebDesmoglein-2 (DSG2) is an integral component of desmosomes, maintaining cell-cell adhension in multiple cancers. It has been well studied in epithelial cells, cardiomyocytes and primary prostate cancer, colon cancer, skin squamous cell carcinoma, except for cervical cancer. Hence, we performed this … WebDesmoglein-2 is an integral component of desmosomes, which are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmogleins and desmocollins connect extracellularly via homophilic and heterophilic interactions. bofrost penne rialtoWebMar 18, 2015 · Following microarray and gene network analysis, we demonstrate that Dsg2 caused a profound change in the transcriptome of keratinocytes in vivo and … global tech layoffs

"WebDSG2 is part of cluster 60 Keratinocytes - Epithelial cell function with confidence i Confidence is the fraction of times a gene was assigned to the cluster in repeated … " - Dsg2 gene and cancer

Dsg2 gene and cancer

DSG2-AS1 Gene - GeneCards DSG2-AS1 RNA Gene

WebFAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT1 and FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by γ‑secretase to release intracellular domain (ICD). WebDSG2 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, DSG2 Genome Browser, DSG2 References DSG2 - Explore an overview of DSG2, with a …

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WebNov 18, 2024 · Methods: A gene ontology enrichment analysis disclosed that DSG2 was highly correlated with CAR. Survival analysis was then performed on 262 samples from the Cancer Genome Atlas, forming "Stage 1A" or "Stage 1B". We therefore analyzed a tissue microarray (TMA) comprised of 108 lung samples and an immunohistochemical assay. WebApr 4, 2024 · a novel pathway of CSTA regulation involving Dsg2; Currently, 13 genes have been associated with the disease but nearly 40 % of clinically diagnosed cases remain …

WebMar 21, 2024 · GeneCards Summary for DSG2 Gene. DSG2 (Desmoglein 2) is a Protein Coding gene. Diseases associated with DSG2 include Arrhythmogenic Right … WebJun 3, 2024 · DSG2 was identified by bioinformatic analyses. DEA of prognosis-related genes identified 24 upregulated genes and 171 downregulated genes in CC compared with ANTs. The volcano plot and heatmap of the differentially expressed genes (DEGs) …

WebApr 13, 2024 · Description. FH, PH and RAS Kit analyzes 11, 11 and 30 genes and covers Familial Hypercholesterolemia (FH), Pulmonary Hypertension (PH) and RASopathy (RAS) related disorders, respectively.. Genes Tested for FH. ABCA1, ABCG5, ABCG8, APOA5, APOB, APOE, LDLR, LDLRAP1, LIPA, LPL, PCSK9 . Genes Tested for PH WebMicroGen Health provides a cardiovascular genomic testing panel that can present clues on genetic factors likely to contribute to disorders like cardiomyopathies, arrhythmic patterns, and thoracic aortic aneurysms and dissections to combat this possible prognosis. Our experts and trained technicians are here to offer a timely and specific ...

WebMar 29, 2024 · Gene type: protein coding Also known as: HDGC; CDHF5. See all available tests in GTR for this gene; Go to complete Gene record for DSG2; Go to Variation …

WebClinical genetic testing is available for the following ARVD/C-associated genes. Mutations in these 6 genes account for ARVD/C in 40-50% of patients screened: Plakophilin-2 (PKP2) Desmoplakin (DSP) Desmoglein-2 (DSG2) Desmocollin-2 (DSC2) Plakoglobin (JUP) Transmembrane protein 43 (TMEM43) bofrost philippe cesarWebGenes → FAT4 gene FAT4 gene FAT atypical cadherin 4 Normal Function The FAT4 gene provides instructions for making a protein that is found in most tissues. The protein spans the membrane surrounding cells so that part of the protein is outside the cell and part of the protein is inside the cell. bofrost penzbergWebMar 12, 2024 · Breast cancer is a highly heterogeneous disease resulting in diverse clinical behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that is commonly perturbed in cancers. The aim of this study is to characterize the relationship between DNA methylation and aberrant gene expression in breast cancer. We analysed … global techmartWebDesmoglein-2 (DSG2) Desmocollin-2 (DSC2) Desmoplakin (DSP) Plakoglobin (JUP) Patients with ARVD/C are commonly found to have genetic abnormalities in the genes … bofrost paellaWebApr 5, 2024 · Our previous integrative study in gastric cancer discovered cryptic promoter activation events that drive the expression of important developmental genes. However, it was unclear if such cancer-associated epigenetic changes occurred in cancer cells or other cell types in bulk tissue samples. An integrative analysis consisting of RNA-Seq and … global tech link phone companyWebDSG2. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas … bofrost pitchWebMar 29, 2024 · Go to Variation Viewer for DSG2 variants Summary This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. bofrost pisa