Chunshan gui and oatp1b1

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August undefined, 2024

WebAbstract: The two organic anion transporting polypeptides (OATPs) 1B1 and 1B3 are expressed at the sinusoidal membrane of hepatocytes. They have a broad and overlapping substrate specificity and transport many endobiotics and drugs. WebThis type of analysis has been previously successfully used to determine the type of interaction of OATP1B1 with a wide range of physiological substrates and fibrates (Gui et al., 2009; Yamazaki ...

Role of transmembrane domain 10 for the function of organic …

WebChunshan Gui Brett Wahlgren Gerald Lushington Bruno Hagenbuch Evidence shows that drug-drug interactions can occur at the level of drug transporters such as the organic anion transporting... WebChunshan Gui - College of Pharmaceutical Sciences, Soochow University, 199 Renai Road, Suzhou Industrial Park, ... polypeptides OATP1B1 and OATP1B3 are highly … porsche yellow color

Cloning/characterization of the canine organic anion transporting ...

WebJianqing Ruan, and Chunshan Gui* Cite This: ACS Omega 2024, 6, 35844−35851 Read Online ... (OATP1B1), OATP1B3, OATP2B1, Na+/taurocholate cotransporting polypeptide (NTCP), organic cation transporter 1 (OCT1), and OAT2, have been investigated to see whether they are involved in the hepatic uptake of PSP. An in vitro cell-based study ... WebAug 6, 2024 · A number of drug-drug and drug-food interactions have been associated with OATP1B1 and 1B3, affecting the pharmacokinetics and pharmacodynamics of their … WebWe have used OATP1B1- or OATP1B3-expressing Chinese Hamster Ovary cells on 96-well plates and determined uptake of fluorescein-methotrexate (FMTX). We validated the assay with known inhibitors and screened the well characterized Prestwick library of 1120 drugs. irish high court search

Influence of Drug Formulation on OATP1B-Mediated Transport of ...

(PDF) Human Organic Anion Transporting Polypeptides 1B1

WebSep 2, 2008 · Three-dimensional model of the OATP1B3/CCK-8 complex. A side view (A) and a view from the intracellular side (B) are presented. Helical segments of the protein are shown in cylinders; the three residues Y537, S545 and T550 in TM10 are shown in ball-and-stick and in orange; CCK-8 is shown in ball-and-stick and in purple. WebFeb 8, 2008 · Chunshan Gui, a Yi Miao, a Lucas Thompson, a Bret Wahlgren, a Melissa Mock, b Bruno Stieger, b and Bruno Hagenbuch a, c ... transport, we developed Chinese Hamster Ovary (CHO) cell lines stably expressing OATP1B1 or 1B3 at high levels. OATP1B1- and 1B3-mediated estradiol-17β-glucuronide uptake was inhibited by several … porsche zentrum olympiapark teamWebDec 24, 2024 · Taken together with our previous results 7 that the mutations of OATP1B1*5, *15 and CYP2C9*2, *3 significantly affect the transport and metabolism of glimepiride and gliclazide, it can be deduced ... irish highlights trafalgar

"WebMay 29, 2014 · Chunshan Gui Authors' Affiliations: ... Transport of paclitaxel, docetaxel, and cabazitaxel was studied in vitro using various cell lines transfected with OATP1B1, OATP1B3, or the rodent equivalent OATP1B2. Pharmacokinetic studies were done in wild-type and OATP1B2-knockout mice in the presence or absence of polysorbate 80 (PS80) … " - Chunshan gui and oatp1b1

Chunshan gui and oatp1b1

Role of transmembrane domain 10 for the function of organic …

WebOATP1B1, OATP1B3, and OATP2B1 signiﬁcantly trans-ported PSP with their transport activities 2-fold greater than that of empty vector control, while human NTCP, OCT1, and … WebFeb 8, 2008 · OATP1B1- and 1B3-mediated estradiol-17beta-glucuronide uptake was inhibited by several pregnane X receptor ligands in a concentration dependent way. …

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WebDec 16, 2024 · OATP1B1, OATP1B3, and OATP2B1, with OATP1B3 showing the highest transport eﬃciency. The Kmvalues for OATP1B1-, OATP1B3-, and OATP2B1-mediated PSP uptake were 11.3 ± 1.5, 7.0 ±1.5, and 5.1 ±1.0... WebIn this study, we investigated the molecular mechanism for this substrate selectivity of OATP1B1 by constructing OATP1B1/1B3 chimeric transporters and by site-directed …

WebSep 16, 2009 · The liver-specific organic anion transporting polypeptides OATP1B1 and OATP1B3 are highly homologous and share numerous substrates. However, at low concentrations OATP1B1 shows substrate selectivity for estrone-3-sulfate. WebDec 24, 2024 · Taken together with our previous results 7 that the mutations of OATP1B1*5, *15 and CYP2C9*2, *3 significantly affect the transport and metabolism of glimepiride …

WebAug 9, 2008 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (Over 39 million articles, preprints and more) WebChunshan Gui1, Amanda Obaidat1, Rathnam Chaguturu2,3 and Bruno Hagenbuch*,1,2 ... hibitors for OATP1B1 and OATP1B3. We have used OATP1B1- or OATP1B3-expressing Chinese Hamster Ovary cells ... 2010, Volume 4 Gui et al. used this assay to screen the Prestwick library for modulators (inhibitors or stimulators) and confirmed several hits by

WebApr 1, 2010 · Author links open overlay panel Chunshan Gui a, Bruno Hagenbuch a b. Show more. Add to Mendeley. Share. Cite. ... (Hagenbuch and Gui, 2008, König et al., 2006). Mice and rats have only a single transporter in the OATP1B family that is the ortholog of human OATP1B1 and OATP1B3 which arose through gene duplication after …

WebJun 30, 2011 · Chunshan Gui et al. have confirmed that ursolic acid is a selective OATP1B3 and OATP1B1 inhibitor (Chunshan et al. 2010 ). Therefore, there may be an interaction between ursolic acid and rosuvastatin. A reasonable combination use of rosuvastatin and herbal medicines containing ursolic acid has important clinical value. porsche yorklandWebChunshan Gui Organic anion transporting polypeptide 1B1 (OATP1B1) is a key hepatic uptake transporter whose inhibition could lead to adverse drug-drug and drug-food interactions. porsche yearly serviceWebChunshan Gui a and Bruno Hagenbuch a, b Author ... nothing is known about their OATP1B1/1B3 ortholog. Therefore, we cloned and characterized the first canine organic … irish higher level junior certWebChunshan Gui1 and Bruno Hagenbuch1,2* 1Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 ... OATP1B1. Gui and Hagenbuch PROTEIN SCIENCE VOL 18:2298—2306 2299. sulfate transport from 70% (chimera T7-12) to 32% (chimera T9-12) and 3% (chimera T11-12). … porsche zell am see teamWebMar 1, 2010 · Comparison of OATP1B1- and OATP1B3-mediated transport of fluorescent substrates. Uptake was measured with 1 µM of the indicated fluorescent compounds on 24-well plates for 30 min. Values are means ± SE of two combined independent experiments each performed with triplicate determinations. porsche zoom backgroundWebJun 30, 2011 · At present, Chunshan Gui et al. have confirmed that ursolic acid was the selective OATP1B3 and OATP1B1 inhibitor (Chunshan et al. 2010). Therefore, the drug … irish hibernianWebChunshan Gui Brett Wahlgren Gerald Lushington Bruno Hagenbuch Evidence shows that drug-drug interactions can occur at the level of drug transporters such as the organic anion transporting... irish hexagon rocks